Unilateral Bullae

History
The patient is a 28 yo man referred on a walk-in basis with an eight month history of a bullous eruption on the dorsum of his left hand. He gets one or two painless lesions a month. No history was sent over with the patient and he is a poor historian. His medications include Welbutrin, Clozeril and Soma (carisprodol/aspirin)


Exam:
The only findings are on the dorsum of the left hand. Here, there is a hemorrhagic bulla, a vesicle and areas of mild erythema at sites of previous lesions.





























Biopsy:
I suspect fixed drug or pseudoporphyria cutanea tarda. I biopsied the small papule and the edge of the bullae and made a follow-up appointment.
Path Report:
A subepidermal separation, individually necrotic keratinocytes , and a sparse superficial perivascular lymphocytic infiltrate with occasional neutrophils .
NOTE : (A and B). Amphophilic globular material is seen deposited in the dermis and around blood vessels in both specimens. This material is P.A.S. stain positive, and stains negative for amyloid and elastic tissue. The differential diagnosis could include porphyria cutanea tarda , although this is usually less inflammatory. A subepidermal autoimmune bullous disorder could also be considered. An additional biopsy for direct immunofluorescence may be of help.


Laboratory Studiess:
CBC normal, LFTs normal, ferritin normal. Hep B and C negative, All urinary porphyrins well within normal levels. Uroporphyrin: 9.6 ug (nl < 30.0) Coproporphyrin 40 ug (normal < 65/24 hr)

Discussion: This is likely pseudoporphyria cutanea tarda. A similar case has been reported. Your comments are welcomed.

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Mystery Rash in Runners

The Williams Cross Country running team went to a meet on the Connecticut shore on Saturday, October 28. There had been a big storm the previous day. The course took them through brackish water sometimes thigh deep. Within a 24 - 48 hours, around half of the runners had developed intensely pruritic lesions on arms and legs. The vast majority of the lesions were on exposed skin. The primary lesion appears to be a juicy papule or a clear vesicle. Some of these have crusted over in a few days. The lesions are discrete. They do not have the linear pattern characteristic of phytocontact dermatitis from a plant such as poison ivy. The pictures were taken of the legs of an 18 yo woman and a 21 yo man. The lesions were quite similar.




It's likely that this is from something dispersed in the brackish water they ran through. Runners from other schools were affected as well. About 50 runners from Williams College developed the eruption.

The possibilities include:
Atypical plant contact dermatitis (Some plant toxin such as urushiol churned up by the storm and floating in the water.)
Jellyfish nematocysts free floating after the storm and blown in
Bird schistosomes -- this is severe for that.
Bacterial infection (a culture was taken from one student and results were not specific)

Do you have other thoughts? What is your opinion?

Solution: The Cross Country course was redirected after the storm. A new path was cut though brush to circumvent a brackish area. It is likely that the new path went through poison ivy. The appearance of the rash 24 - 48 hours after exposure in the majority of runners and the quality of the itch suggests rhus contact dermatitis.

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Teenager with a Red Nose

This 14 year-old girl has had a red nose for the past two years. It followed as severe sunburn. Her nose never looks normal. Occasionally, there are small cysts with bleeding and purulent drainage.
















I have seen this picture occasionally in teenagers. It looks like a rosacea variant. I'd also consider demodex.

Your suggestions are anticipated and will be welcome.

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30 year old woman with changing mole

This 30 yo woman has noticed an enlarging pigmented lesion in her right axilla for almost a year. Her mother, a registered nurse, asked her to see a dermatologist. Her husband did not notice it.
The patient has Type II skin. The general cutaneous exam was unremarkable save for a 1.2 cm in diameter barely elevated plaque. There is a play of pigment and outline is irregular.

An excisional biopsy was performed.

Pathology: Malignant melanoma in situ , superficial spreading type. (Read by H. Byers of BU Skin Path who took photomicrographs) "The specimen exhibits a marked nested and lentiginous melanocytic proliferation with large severely atypical epithelioid cells. There is irregular nesting, focal confluent lentiginous melanocytic proliferation and cellular dyshesion."









































She is scheduled for a wider excision, 0.5 cm on either side. No further work-up other than regular follow-up visits.

Your thoughts are appreciated.

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Positive Band Aid Sign

Most dermatologists know about the "positive band aid sign." To me, it means a skin cancer has been lurking there for a while.

This 82 yo man came in with a one year history of a "sore" on his back. The drainage stained his shirt. When the band aid was removed, there was a one cm in diameter clean friable tumor, most likely a basal cell.

The lesion was shave biopsied and desicated and curetted. I'll affix a copy of the biopsy report when I get it.

How many of you use the term "Positive band Aid Sign?"

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BCC of Eyelid

This 43 yo man has a one year history of a lesion of the left lower lid. It measures 8 mm in diameter.
Biopsy from "X" confirms "nodular BCC."
Question: What is best therapy?
1) Mohs
2) Mohs + closure by ophthalmic plastic surgeon
3) Ophthalmic plastic surgeon handle all
4) Another approach

Cada vendador allabe sus agujas.
Every peddler praises his needles.

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Therapeutic Question

The patient is an 83 year-old woman with a two year history of a lesion on the nose.
Clinically, this is a basal cell. My question is what you would recommend as therapy and why?

1) Micrographic surgery with forehead advancement flap.*
2) Micrographic surgery with graft or allowed to heal by secondary intention.
3) Radiotherapy
3) Other






















* Repair of defects on nasal sebaceous skin.
Dzubow LM.
Department of Dermatology, University of Pennsylvania Health System, Philadelphia, 19085, USA. leonarddzubow@comcast.net
BACKGROUND: Reconstructive procedures performed on sebaceous nasal skin are prone to partial flap necrosis, scar spread and inversion, and tissue mismatch. An ideal repair would optimize vascular integrity, minimize closure tension, and use adjacent tissue. OBJECTIVE: The purpose of this article is to describe a flap design and dynamics that permit satisfactory reconstruction of small- to medium-sized defects on nasal sebaceous tissue. METHODS: A modified advancement flap is described that may be used on central and off-midline defects of the nasal tip. RESULTS: Use of the modified advancement flap resulted in good cosmetic results with few adverse postsurgical events. CONCLUSIONS: The modified advancement flap satisfies the requirements of a hardy blood supply, minimization of closure tension, and use of adjacent tissue. The surgical results are predictable and rarely associated with complications.

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